Anne-Sophie Dugast, M.D.
Boston General Hospital and Ragon Institute
Title: "Impact of non-neutralizing antibodies on SHIV challenge"
Description: In addition to their capacity to neutralize the virus, antibodies display pleiotropic effects following the recruitment of innate immune cells expressing FcRs (Fc receptors) on their surface. While antibodies with neutralizing activity confer protection against SIV infection, it is plausible that additional antibody functions may be equally important in providing protection. In both the human and non-human primate models, mounting evidence supports the significance of potent antibody dependent cellular cytotoxicity (ADCC) activity in protection against disease progression. Our project intends to address the hypothesis that ADCC-inducing, but non-neutralizing antibodies from natural infection can mediate sterilizing protection in vivo through the recruitment of innate immune effector functions, in a rhesus macaque SHIV model.
Mentors: My mentors are Galit Alter and Dan Barouch. I have been working with Galit Alter for the last 2 years as a post doctoral fellow trying to understand how antibodies may provide specificity to the innate immune system for virally infected cells using samples from well-defined cohorts of HIV infected individuals. Dr. Barouch is a leading expert in the HIV vaccinology community and specializes in experimentation in non-human primate models, whose mentorship will provide me with guidance and access to rhesus macaques for in vivo challenge experiments.