Possible Vaccine Outcomes

It is important to realize that scientists are still learning about how vaccines might work to prevent HIV infection. An HIV vaccine may be totally successful in preventing infection, known as "sterilizing immunity." Sterilizing immunity may be possible in 100% of the population, or perhaps only in certain groups. In another scenario, a preventive vaccine may not prevent primary infection, but decrease the possibility of HIV transmission from an infected individual to another person. Yet another possibility is that a vaccine may slow the process of infection, so that even if a person becomes HIV infected, the vaccine helps the vaccinated individual remain healthier longer. The following list provides details about the variety of ways that scientists believe a preventive HIV vaccine might work.

Different Results:

Sterilizing immunity
  • complete protection from HIV infection
  • no detectable HIV at any time
  • no transmission of HIV to others

Transient infection
  • infection occurs, but the immune system is able to detect and kill off infected cells
  • disease process does not advance, because immune system is able to control the infection
  • no detectable HIV at later times (6-12 months after infection)
  • seroconversion (becoming HIV+) may or may not occur
  • transmission to others might occur within a brief window of time, or might be completely prevented

Long-term controlled infection
  • undetectable or very low viral load throughout life
  • no harmful drop in CD4 cells
  • no immunodeficiency disease progression (HIV does not advance to AIDS)
  • seroconversion likely
  • transmission to others prevented or greatly diminished

Altruistic vaccine
  • little benefit to vaccinated individuals; however, the vaccine could help to prevent transmission of infection to others
  • viral load in mucosal secretions would remain low, so the vaccinated individual may remain healthy for a longer period of time
  • HIV transmission to others prevented or greatly diminished



Related Link
Multimedia Presentation: Where's the AIDS Vaccine? Laurence Peiperl, M.D., University of Calfornia San Francisco
A fascinating lecture about the challenges of finding an HIV vaccine. Can be heard through RealAudio.