The HIV Vaccine Trials Network (HVTN) is the world’s largest publicly funded multi-disciplinary international collaboration facilitating the development of vaccines to prevent HIV/AIDS. The HVTN conducts all phases of clinical trials, from evaluating experimental vaccines for safety and immunogenicity to testing vaccine efficacy.

graphic of HVTN structure

Over the past decade, the HVTN has aimed to improve the process of designing, implementing, and analyzing vaccine trials. Several major achievements include streamlining protocol development while maintaining input from diverse stakeholders, establishing a laboratory program with standardized assays and systems allowing for reliable assessments across trials, setting statistical standards for the field, and actively engaging with site communities. These achievements have allowed the HVTN to conduct over 50 clinical trials and make numerous scientific contributions to the field.

The importance of public support

The HVTN recognizes the importance of public support in finding a vaccine against HIV/AIDS. Our staff and volunteers from around the globe work actively to help community members understand the science of HIV/AIDS vaccines, as well as research methods and clinical trial processes. Through our efforts, we hope to dispel some of the misconceptions that surround HIV/AIDS and studies involving human participants.

Funding is provided by public and private sources; the National Institute of Allergy and Infectious Diseases (NIAID) of the U.S. National Institutes of Health (NIH), an agency of the U.S. Department of Health and Human Services (DHHS), is our main funder and the sponsor of most of our trials. Another significant funding source is the Bill & Melinda Gates Foundation (BMGF). The Network, BMGF, and NIAID have a close, cooperative working relationship, with shared attention to intellectual and scientific issues.

The Network’s Clinical Research Sites are located at leading research institutions in over 30 cities on five continents. Internationally renowned researchers in HIV vaccines and prevention lead these units and contribute to the Network’s scientific agenda. The Network’s headquarters are at the Fred Hutchinson Cancer Research Center in Seattle, Washington.

HIV Vaccine Trials Network - A Life's Work

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Researchers at the HIV Vaccine Trials Network are working toward the goal of welcoming an AIDS-free generation - and they're doing it by developing an effective, global HIV vaccine. View video

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The HVTN Core Communications Unit has been working on producing short videos of community outreach site staff. We ask them to answer the question, “I work toward an HIV vaccine because….” We plan to use these videos as a way of generating interest and understanding of the work we will be doing in southern Africa and the passion that drives that work.  
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